Overview of Anti-Aging Therapy for Biohackers
Anti-aging medicine is about 20 years old and the fathers of this new approach to medicine are all alive and well. They are mainly based in the USA, and the first of them is Robert Goldman (MD, a specialist in sports medicine, is the founder of the US National Sports Medicine Commission, a co-founder of the American Academy of Anti-Aging, an endocrinologist, professor, has a degree in surgery, has written 40 books on sports and anti-aging medicine) said that with modern knowledge in the field of endocrinology, biological age and calendar age can be separated safely. The second is the famous founder of growth hormone therapy, Ronald Kants. An interesting fact: growth hormone was first introduced to the child in 1958 (MORIS SLABEN). Growth hormone was obtained for a long time, until 1996, from the pituitary body of corpses, about 1000 corpses were used per injection. Then, over time, part of the patients began to develop a characteristic picture - KEYNFALDAJACOBA disease (dementia, muscle weakness. It was believed that this was due to an infectious factor). But we will return to growth hormone ... I also can not help but mention the outstanding gynecologist-endocrinologist Susie Valley, who developed the famous Valley Protocols - sex hormone replacement therapy for patients after removal of the uterus and ovaries, as well as endometriosis and other complex female pathologies, and not only for the purpose of rejuvenation. In her works, she uses only transdermal hormonal preparations with high dosage variability. But we will return to growth hormone ... I also can not help but mention the outstanding gynecologist-endocrinologist Susie Valley, who developed the famous Valley Protocols - sex hormone replacement therapy for patients after removal of the uterus and ovaries, as well as endometriosis and other complex female pathologies, and not only for the purpose of rejuvenation. In her works, she uses only transdermal hormonal preparations with high dosage variability. But we will return to growth hormone ... I also can not help but mention the outstanding gynecologist-endocrinologist Susie Valley, who developed the famous Valley Protocols - sex hormone replacement therapy for patients after removal of the uterus and ovaries, as well as endometriosis and other complex female pathologies, and not only for the purpose of rejuvenation. In her works, she uses only transdermal hormonal preparations with high dosage variability.
In Europe, there are also the founders of Anti-Age Medicine. European anti-aging school, headed by hereditary doctor of medicine, endocrinologist Thierry Ertog, we owe him the free distribution of melatonin worldwide and the availability of this pineal gland hormone in all pharmacies (we sell it as melaxen).
The concept of anti-aging medicine includes not only hormone replacement therapy, but also dietetics, nutraceuticals, pronounced and proper physical activity.
In the history of mankind, aging is a natural biological process, and only in recent years, part of the medical community began to consider aging as a pathological process that can and should be influenced in order to maintain the quality of life. The concept and definition of age became deeply individual and the biological age was separated from the chronological.
Aging has become a "tribal disiz", that is, it is regarded as a treatable disease. In aging, a number of syndromes are distinguished, in particular: mitochondrial fatigue, leaky intestine syndrome, and so on.
On theories of aging, we dwell briefly on the achievements that are today. Everyone has heard the telomerase theory of aging with Elizabeth Parish, which compensates for the age-related lack of telomerase. There is also an active study of genes and one cannot fail to note the famous experience with worms nematodes, which in 1996 managed to rearrange some of the genes that disable aging - the worms lived twice as long. It can be argued that the biological age is given and there is a Hayflick limit (that is, a cell divides a certain number of times and dies) And I send you again to the nematodes, in other words, it is possible to overcome the Hayflick limit. Aging is now being studied at the intracellular level (Grace Wong, Department of Molecular Oncology in Genschnich), by the way, they first synthesized recombinant growth hormone. So, aging is largely associated with the breakdown of proteins within the cell, as well as the destruction of DNA and RNA by which proteins are formed. Skin, hair and bones are made up of proteins, when proteins degrade, the same happens with the structures they are made of (skin becomes wrinkled, hair falls out, bones lose density). What makes proteins degrade? Free radicals found in all cells that use oxygen to generate energy. Free radicals activate proteases that damage the protein in the cell. When a significant amount of protein is damaged, the cell dies, after which DNA fragmentation occurs. Antioxidants, such as vitamins D and C, can remove free radicals, preventing the proteases from activating, well, growth hormone, this huge molecule, consisting of 191 amino acids, is a direct protease inhibitor. So the axis of the pituitary-endocrine glands developed by Vladimir Dilman can also be affected.
Let us dwell more on hormone replacement therapy and neuroendocrinology.
The basic paradigm of neuroendocrinology is: "We age because our hormones decline, our hormones do not decline because we age." This is the main meaning of all ACTIONS, analyzes and therapies. Anti-aging endocrinology introduces not only such a concept as “normal hormone levels”, the range and range of which is wide, but also “ideal hormone levels”. The optimal range of hormone levels is also a misnomer for antiaging medicine. For example, the level of estrogen hormone in a 75-year-old woman should be equal to -0- and this is normal for her age, but this level of estrogen leads to pronounced decrepitude of the brain, cardiovascular dysfunction, severe osteoporosis, etc.
Hormones, as we know, are general regulators of the body. They act on the chromosomes and activate certain pieces, departments (call them convenient) of the chromosomes and thus regulate the activity of cells. There are catabolic hormones - corticosteroids, adrenaline; and anabolic - somatotropin, testosterone, DNEA. Hormones are also divided into central and peripheral (autocrine and paracrine) - this includes neurotransmitters (seratonin, dopamine). Hormones can also be divided into hormones of youth - somatotropin, testosterone and hormones that promote aging - cortisol, insulin. But the same hormone can play a very different role, depending on whether it is in the female body or in the male one, and how much it is there: for example, estrogen in excess in the male body is an aging hormone.
It is impossible to reduce the action of hormones only to narrowly specific ones. For example, testosterone is the main male sex hormone, it is also anabolic and paracrine, as it has a powerful effect on both the male and female psyche. What we know about the synthesis and transportation of hormones relates mainly to thyroid hormones and much is still unknown. For example, the half-life of oxytocin is 7 seconds, nevertheless, in such a short time, it has a powerful effect on the central nervous system, causes a good mood, friendliness, enhances the love of loved ones and is used as a nasal spray to treat age-related depression.
The use of bioidentical hormones in anti-aging therapy, and not just synthetic ones, is very important. What's the Difference? In bioidentical hormones, the rotation of amino acids left-handed and right-handed coincides with the natural hormone; in other words, THE CORRECT SPATIAL ORIENTATION OF THE HORMONE MOLECULE IS NEEDED, only in this case it will be bioidentical. Steroids, for example, sex hormones are ring-shaped, but in space they are in the form of a chair or boat (these are natural or bio-identical hormones). Synthetic hormone is just a set of acids without any characteristics. In anti-aging medicine, hormone delivery routes are important; transdermal access for sex hormones is preferred. When taking the hormones of wasps, protein fractions are formed in the liver that increase blood coagulation.
Optimizing hormone levels leads to the first step in stimulating your own stem cells.
We are all well aware that there are diseases directly related to aging: In the USA, at the age of 65 years, mortality from heart disease is one third of the total number of deaths, cancer is 20-25%; cerebrovascular diseases - 10%, chronic obstructive pulmonary diseases - 5%, pneumonia - 4%, diabetes - 6%, and other causes of about 15%.
Hormones, when used properly, protect against cancer and chronic inflammation, and prevent the development of hypertension and other vascular pathologies. The opinion that hormones cause cancer is outdated, like Jurassic dinosaurs! For example, the use of estrodiol without the use of progesterone is unacceptable, because it negatively affects the endometrium. A wider use of melatonin with age as an antitumor hormone is important.
Another thing is that the use of hormones must be reasonable and individual. HRT can be used only on the examined and prepared body
Anti-aging medicine is a set of activities consisting of the use of hormones, nutrients, diet and physical activity.
The start of an anti-eaging program begins with a diet. Danel Radmen believes that starting from the age of 35, against the background of a decrease in hormones, a person’s body turns from green and young to soft and bulk, the mass of fat increases by 50 percent, while the lean mass, which consists of the mass of muscles, bones and organs reduced by 30 percent. Correction of insulin peaks in the blood, refusal of sweets, harmful fast carbohydrates, dietary adjustment of insulin levels will already lead to an improvement in well-being and will add strength. It will also save most healthy people from insulin resistance and hyperinsulinemia. Removing type A casein from the diet will reduce chronic inflammation and allergization, removing gluten from the diet will also relieve the body. improve bowel function.
Physical activity is not excessive, but regular is our everything. Only physical activity and short non-stress hunger strikes can stimulate our own growth hormone.
Nutrients - a class of elements that are normally present in our body and decrease with age, or their quantity changes. For instance. the young body is able to synthesize sucrose in the liver, but with age, this ability fades. Also included in the class of nutrients are vitamins, micro and macro elements, essential amino acids, unsaturated fatty acids, etc. Proper replenishment of these elements is part of antiaging therapy. A good help in this matter is the determination of the level of vitamins in the blood: we only determine vitamin D, B12, folic acid, and it is also possible to determine homocysteine as a vascular aging factor and the accumulation of errors during DNA digestion. I will not dwell on this in more detail, since this is the topic of a separate article.
Let's return to hormones and age. According to Professor Khamoshina, the average fertility age among Russians has crossed the 35-year threshold, moreover, 35-year-olds give birth more often than 20-year-olds, and every 12 abortions were performed in women older than 45 in 2012. In the US, these numbers are even greater. The average age of women in labor is approaching 40 years. In addition, in the United States, women over 60 years of age with a pronounced replacement effect resort to hormone replacement therapy (in particular, they use the Valley protocols). Well, a few more figures - there are more people over 60, the growth of older people was 8.1 percent in 1950 and 10 percent in 2000, by 250 this figure would be 22.1 percent. Conclusion: you need a quality of life.
The decrease in the level of sex hormones begins at about 35 years old. Now these numbers are even lower due to malnutrition. By reducing, in particular, omega-3 in food to catastrophically low rates.
Should hormone replacement therapy always start with sex hormone replacement?
No not always. We know that hormones have multiple effects and synergies, in some cases, antogonism. In appointments, we rely on tests, studies, anamnesis and complaints made by the patient. Earlier treatment at the age of 40, for example, allows you to lead a patient for a long time without the use of sex hormones (I'm talking about healthy people), all chronic inflammations at the time of applying for antiaging therapy should be compensated. Often, therapy starts with the use of growth hormone or testosterone in women. Compensation for thyroid hormones is mandatory, as well as diet and physical activity. If necessary, the level of vitamins and other nutrients is adjusted.
Before any anti-aging program begins, a survey is needed!
The possibility of genetic analysis is very good, since there are well-established patterns of predisposition to a particular type of oncology, and indicators in which, for example, Angelina Jolie, removed both mammary glands. So this is a great help ... Do not forget that our HRT affects genes. If everything is fine here, then we will examine the hormonal profile and a number of biochemical parameters. The patient’s wishes are also important, a thorough examination of complaints and psychological status (for this, in addition to examining and collecting an anamnesis, questionnaires are used), the patient’s age is also important. The earlier the treatment (i.e., I mean after 40 years old), the better and easier it is to keep youthful. Turning to menopause and the postmenopausal period leads to a faster appointment of direct sex hormones, early treatment makes it possible to lead a patient for quite a long time without direct sex hormones. Schemes for managing patients on growth hormone with regular physical activity and short hunger strikes are very popular in the USA, which allows you to maintain muscle mass and the level of your own sex hormones for a long time. Correction of insulin levels is mandatory and early. Ideally, of course, when a person eats right all his life. Getting rid of insulin peaks leads to maintaining the correct body weight, prevents obesity and, in general, age-related increase in body weight. On average, the weight in women with unchanged nutrition increases by 3.5 kg per year with an age after 40. which allows you to maintain muscle mass and the level of your own sex hormones for a long time. Correction of insulin levels is mandatory and early. Ideally, of course, when a person eats right all his life. Getting rid of insulin peaks leads to maintaining the correct body weight, prevents obesity and, in general, age-related increase in body weight. On average, the weight in women with unchanged nutrition increases by 3.5 kg per year with an age after 40. which allows you to maintain muscle mass and the level of your own sex hormones for a long time. Correction of insulin levels is mandatory and early. Ideally, of course, when a person eats right all his life. Getting rid of insulin peaks leads to maintaining the correct body weight, prevents obesity and, in general, age-related increase in body weight. On average, the weight in women with unchanged nutrition increases by 3.5 kg per year with an age after 40.
With age, all hormone levels decrease, sometimes smoothly, but more often spasmodically. Part of the hormones with age may grow unusual or sensitivity to them will change. Compensating and balancing hormones is the task of anti-aging medicine. With aging, it is also possible to increase individual hormones, which usually indicates the development of pathology (this is against the background of a general decrease in hormones); if we see a mismatch and an increased level of estrogen (most often this is due to female pathology, such as endometriosis), then we need a consultation with a gynecologist-endocrinologist, such as Suzy Valley, and individually selected therapy and correction. Quite often, prolactin in men is increased with age, especially with undiagnosed pathology, hyperprolactinemia is most often associated with chronic fatigue syndrome — then passive rest, yoga, perfectly shows itself in the therapy of oxytocin, melatonin, etc. With age, it is very, very often elevated in men and estrogen, i.e. we are faced with a picture of normal or decreased testosterone and increased estradiol in men. Of course, with age this happens against the background of aromatization of testosterone in the liver, in other words, such a man will have less and less active good dehydrotestosterone and more estradiol. In this case, prescribe drugs that suppress the aromatization process, say with the help of the American drug miomina. Also, such a man just needs to adjust the liver functions, normal nutrition, sports, a categorical refusal of beer. Men with increased estradiol are seen by their behavior - more emotional. I like the example of table tennis, when men accompany the ball with screams. Such men are more conflicted, verbose. Also, in addition to changes in behavior and emotionality, we know that estradiol in the male body leads to proliferation of prostate cells and leads to adenoma. In such cases, correction is simply necessary along with the guidance of a urologist.
In women with aging, in addition to sex hormones, cortisol can be increased as a stress indicator. Women are generally more prone to a lack of neurotransmitters (from 35 to 55 years old, the level of neurotransmitters in women is generally lower than in men), but it is not clear what this is connected with. It is believed that with greater social responsibility among women (USA, Europe), therefore, older women are more likely to increase cortisol. Also, women often have hyperinsulinemia and insulin resistance, nutrition regulation in this case is simply necessary. The remaining hormones are reduced, and women are also prone to a faster decrease in thyroid hormones.
In conclusion, I want to say that you can start anti-aging therapy in deep postmenopausal women. In these cases, DNEA is preferred as the base hormone: it improves the quality of life of the elderly. Anti-ejecting medicine is also applicable to neurodegenerative diseases, cardiovascular diseases, and patients with oncology can also improve their lives.