Determine your bio-age on the profile
Gero and Open Longevity are investigating the effects of drugs and dietary supplements on human bio-aging. After processing all the data, everyone who fills out the questionnaire will be informed of the biological age and the results of the study will be sent. Take the survey and contribute to the study of aging! Gero and Open Longevity
Poll
Many physiological parameters change with age, reflecting changes in the general condition of the body, its “wear” and the chances of a breakdown. For example, the stiffness of the walls of large arteries increases during life and largely determines the risk of death from cardiovascular disease [ 1 ]. Therefore, they learned to determine it: for example, through pulse pressure [ 2 ] or telomere length [ 3 ]. Heart rate variability (HRV) reflects both the cognitive and athletic abilities of the body: how quickly a person solves problems, how much he can run and squeeze in the hall, how quickly he recovers from a load [ 4 ]. With age, this indicator decreases [ 5 , 6 ,7 ].
Medicine has long used the chronological age to assess health-related risks: doctors adjust the medical examination plan depending on the patient’s birth year and pay attention to the early symptoms of age-related problems. Knowing your bio-age is the first step to lowering it.
The most famous example is the bio-age created by Steve Horvath, known as the “Croatian Epigenetic Clock” [ 8 ]: it is counted according to DNA methylation patterns (methylation is a reversible modification of the genome that increases or decreases gene expression depending on the needs and capabilities of the body). Other methods for determining bio-age are based on blood tests [ 9 ], proteome [ 10 ], or even 3D facial images [ 11 ].
Some time ago, the Russian company Gero found that bio-age can be determined by analyzing human locomotor activity [ 12 ] - changes in the intensity of walking during the day: for example, periods of activity in older and sick people are much shorter [13 ]. Now a new scientific article is being prepared there for publication, in which the company's scientists tell how they managed to simplify the models even more without losing accuracy: it turned out that bio-age can be determined from the questionnaire, in which a person is asked about the current state of health and well-being .
This method was discovered by Gero during an analysis of the National Health and Nutrition Examination Survey (NHANES) database. NHANES is a study that was conducted in the United States in 1999-2010. NHANES experts surveyed 30,000 people aged 20 to 85 years, that is, almost over the entire life span of a person, so these data were well suited for creating a bio-age model. The NHANES shortened the long list of questions, leaving only those that reflect current health status while making a significant contribution to predicting bio-age. The person is asked to tell how well he felt in the last 30 days. Questions are related to three aspects: physical health, mental state and healthy lifestyle.
It is surprising that such a simple and cheap data source as a subjective assessment of their health by respondents (what is called self-reported in English) allows you to create a model that is almost as accurate as a model based on more objective data: blood or DNA tests methylation.
While the article was being prepared for publication, Gero decided to test how bio-age responds to the effect of typical biohacker interventions (fasting mimicking diet, metformin and others) on data from living people, and not from lifeless datasets. Ten years ago, when NHANES collected this data, almost no one used supplements to extend and improve life, so there is very little information in the dataset. The scarce data that was found does not allow to reliably assess the effect of taking dietary supplements on bio-age. Therefore, Gero and Open Longevity launched a survey to collect more information and find out how taking specific medications affects their health.
The survey has already gathered more than 1000 participants and showed the first interesting findings:
More than a third of participants practice some form of calorie restriction.
And when we compared the health assessment in the group of Russians and the group of English-speaking respondents, it turned out that abroad more people feel great:
But for really interesting results, you need a lot more data. Take the survey , even if you are not taking any medications - this will help you form a control group.
The success of the study depends on the number of responses. The more people see the profile, the better for everyone. Be sure to share the survey on social networks:
Share on Facebook
Share on Twitter
Or just send a link to a friend: goo.gl/oB1rCJ
The first results of the Gero team in the person of Peter Fedichev and Timofey Pyrkov will present on February 20 at the Health Marker Management Tournament .
Peter Fedichev about the study
Join our fight against aging, fill out a questionnaire about which drugs you take and how you feel. Small but contribution.
Poll
What is bio-age and why is it needed
Many physiological parameters change with age, reflecting changes in the general condition of the body, its “wear” and the chances of a breakdown. For example, the stiffness of the walls of large arteries increases during life and largely determines the risk of death from cardiovascular disease [ 1 ]. Therefore, they learned to determine it: for example, through pulse pressure [ 2 ] or telomere length [ 3 ]. Heart rate variability (HRV) reflects both the cognitive and athletic abilities of the body: how quickly a person solves problems, how much he can run and squeeze in the hall, how quickly he recovers from a load [ 4 ]. With age, this indicator decreases [ 5 , 6 ,7 ].
Medicine has long used the chronological age to assess health-related risks: doctors adjust the medical examination plan depending on the patient’s birth year and pay attention to the early symptoms of age-related problems. Knowing your bio-age is the first step to lowering it.
Methods for determining bio-age
The most famous example is the bio-age created by Steve Horvath, known as the “Croatian Epigenetic Clock” [ 8 ]: it is counted according to DNA methylation patterns (methylation is a reversible modification of the genome that increases or decreases gene expression depending on the needs and capabilities of the body). Other methods for determining bio-age are based on blood tests [ 9 ], proteome [ 10 ], or even 3D facial images [ 11 ].
Some time ago, the Russian company Gero found that bio-age can be determined by analyzing human locomotor activity [ 12 ] - changes in the intensity of walking during the day: for example, periods of activity in older and sick people are much shorter [13 ]. Now a new scientific article is being prepared there for publication, in which the company's scientists tell how they managed to simplify the models even more without losing accuracy: it turned out that bio-age can be determined from the questionnaire, in which a person is asked about the current state of health and well-being .
This method was discovered by Gero during an analysis of the National Health and Nutrition Examination Survey (NHANES) database. NHANES is a study that was conducted in the United States in 1999-2010. NHANES experts surveyed 30,000 people aged 20 to 85 years, that is, almost over the entire life span of a person, so these data were well suited for creating a bio-age model. The NHANES shortened the long list of questions, leaving only those that reflect current health status while making a significant contribution to predicting bio-age. The person is asked to tell how well he felt in the last 30 days. Questions are related to three aspects: physical health, mental state and healthy lifestyle.
It is surprising that such a simple and cheap data source as a subjective assessment of their health by respondents (what is called self-reported in English) allows you to create a model that is almost as accurate as a model based on more objective data: blood or DNA tests methylation.
Gero and Open Longevity Experiment
While the article was being prepared for publication, Gero decided to test how bio-age responds to the effect of typical biohacker interventions (fasting mimicking diet, metformin and others) on data from living people, and not from lifeless datasets. Ten years ago, when NHANES collected this data, almost no one used supplements to extend and improve life, so there is very little information in the dataset. The scarce data that was found does not allow to reliably assess the effect of taking dietary supplements on bio-age. Therefore, Gero and Open Longevity launched a survey to collect more information and find out how taking specific medications affects their health.
The survey has already gathered more than 1000 participants and showed the first interesting findings:
More than a third of participants practice some form of calorie restriction.
And when we compared the health assessment in the group of Russians and the group of English-speaking respondents, it turned out that abroad more people feel great:
But for really interesting results, you need a lot more data. Take the survey , even if you are not taking any medications - this will help you form a control group.
The success of the study depends on the number of responses. The more people see the profile, the better for everyone. Be sure to share the survey on social networks:
Share on Facebook
Share on Twitter
Or just send a link to a friend: goo.gl/oB1rCJ
The first results of the Gero team in the person of Peter Fedichev and Timofey Pyrkov will present on February 20 at the Health Marker Management Tournament .
Peter Fedichev about the study
Join our fight against aging, fill out a questionnaire about which drugs you take and how you feel. Small but contribution.