Herpes virus causes Alzheimer's syndrome, other viruses - heart attack and diabetes

    Taking antiviral drugs against herpes reduces the incidence of Alzheimer's syndrome by 10 times . 80 percent of people over 40 have the herpes virus and most are unaware of it.

    Scientists have already sequenced more than 5,500 viruses that can infect mammals. Perhaps in nature there are another 320,000.

    Cytomegalovirus (CMV)


    This group of viruses includes herpes simplex viruses, chickenpox virus (which causes chickenpox and shingles), cytomegalovirus and Epstein-Barr virus (which causes mononucleosis). Up to 90 percent of adults were infected with the Epstein-Barr virus.

    CMV is usually at rest and harmless in the body, but can cause infections, including viral heart infection. Viruses spread by contact with body fluids of an infected person. They can also be transmitted from a pregnant woman to the fetus during pregnancy.

    Rapamycin causes diabetes in mice . So the cause of diabetes should be sought in our immune system. In viruses?

    Next will be described diseases and the following viruses, possibly causing them:
    Epstein – Barr virus (EBV), also called herpesvirus 4 (HHV-4)
    Cytomegalovirus (CMV), also called herpesvirus 5 (HHV-5)
    Varicella zoster virus (VZV), also called herpesvirus 3 (HHV-3)
    Herpes simplex virus -1 (HSV-1)
    Herpes simplex virus-2 (HSV-2)

    Alzheimer's Syndrome


    CA is a complex neurodegenerative disease leading to irreversible loss of neurons, intellectual abilities, memory and reasoning ability.
    Chronic inflammation is considered to be the cause of chronic diseases, including Alzheimer's disease.
    CMV is present in a very high proportion of patients with vascular dementia in the brain ( Lin et al., 2002 ).

    Our findings show a simple and direct mechanism by which herpes infections cause precipitation of the brain amyloid as a protective response. in the brain, explains one of the researchers, Rudolf Tanzi of the MassGeneral Institute for Neurodegenerative Disease (MIND).
    Amyloid beta in the brain specifically wraps particles of herpes to prevent their spread!

    "So we combined the hypothesis of infection and the hypothesis of amyloid into one hypothesis of an antimicrobial response from Alzheimer's."

    Based on past research, scientists have chosen herpes simplex 1 (HSV-1) and herpesvirus 6 (HHV-6) as potential candidates for Alzheimer's connection - HSV-1 is a virus that, by the way, causes herpes.

    The experiments not only showed that viral infections lead to more deposits of amyloid beta, mice divorced with humanoid Aβ were better able to repel HSV-1 damage, suggesting that these proteins (amyloid) are indeed a kind of counter-attack.

    It also matches with studies published just a few weeks ago that showed higher levels of herpes viruses in the brains of people who died from Alzheimer's.

    Cardiovascular diseases


    Herpes simplex virus type 1 (HSV-1) has been recognized as a potential causative agent of cardiovascular disease. Antibodies to HSV-1 are reported to be associated with an increased risk of myocardial infarction and coronary heart disease.

    Previous studies have shown that people who had a positive CMV test are at higher risk for heart disease and this is independent of other risk factors.

    There is increasing evidence that chronic infection is associated with atherosclerosis . Specific organisms, including herpes viruses, increase atherosclerosis in mice with apolipoprotein E (ApoE)

    Thirty-seven percent of the subjects (142 out of 381) were CMV-seropositive. These people had a higher body mass index (1 kg / m2) and systolic blood pressure (3 mmHg), but lower LDL cholesterol (0.2 mmol / L) when measured by age, gender, and diabetes. There were no differences in the values ​​of C-reactive protein (CRP), hemoglobin A1C levels (7%).

    Fifty-eight percent of the subjects (220 out of 379) were HSV-positive. These people had a higher body mass index (2 kg / m2) and systolic blood pressure (4 mm Hg. Art. Above), adjusted for age, gender and diabetes. In contrast to CMV, those who were seropositive for HSV had significantly higher C-reactive protein values.

    Coronary Artery Calcification and CMV / HSV
    CMV-positive individuals had a 1.5-fold odds ratio for calcification compared to the seronegative group. A similar insignificant ratio was observed between HSV-positive serology and calcification.

    The results also show that previous CMV infection may be associated with an increase in atherosclerotic load, as assessed by examining coronary artery calcification. In contrast, there was no statistically significant independent relationship between HSV, H pylori, C pneumoniae, and vascular dysfunction.

    These results complement the work with mice with ApoE deficiency, in which murine gamma superpirus-682 and murine cytomegalovirus3 enhance the atheroma, but not HSV-1. And consistent with clinical signs that CMV, but not HSV-1, is associated with atherosclerosis.

    Type 2 diabetes


    Type 2 diabetes mellitus is a metabolic disorder characterized by high blood glucose levels due to insufficiency or insulin resistance.

    Researchers examined more than 500 people in the late 80s. Of those who had CMV, 17% also had type 2 diabetes. Among those who never had CMV, only 8% had diabetes.

    Here's another study
    Among 1,566 subjects, 206 (13.2%) had type 2 diabetes, and 1,360 patients were non-diabetic. In patients over the age of 65, arterial hypertension and coronary artery disease were more common in patients with diabetes than in controls (all P <0.05). The prevalence of HSV-1 infection was significantly higher in the diabetic than the control group (46.1 versus 36.3%).

    This finding is not consistent with the suggestion that diabetes leads to HSV-1 infection, because among the few pathogens that are thought to be involved in the pathogenesis of cardiovascular disease, only HSV-1 infection, i.e. not Chlamydia pneumonia, cytomegalovirus, or HSV -2 are associated with type 2 diabetes.

    Type 1 diabetes


    Type 1 diabetes develops as a two-stage process. First, a person acquires antibodies against cells in the pancreas, responsible for the production of insulin, a hormone that allows cells to absorb sugar from the bloodstream so that they can burn it for energy. Some children generate antibodies called auto-antibodies because they target human cells but never develop the disease.

    In other children, however, auto-antibodies signal a progressive attack on the body's own immune system against pancreatic cells, killing them and inhibiting the body's ability to produce insulin. When the pancreas can no longer produce enough insulin, a person develops type 1 diabetes.

    Researchers have also found differences in a group of viruses called bacteriophages that infect bacteria in the intestines rather than in human cells. Children carrying bacteriophages that target Bacteroides species, one of the main groups of intestinal bacteria, are more likely to begin on their way to diabetes.

    “Previous studies have shown that changes in Bacteroides species are associated with the development of type 1 diabetes, and here we found that viruses that infect bacteroides are associated with the development of autoantibodies,” said Deva, who is also a professor of molecular microbiology and medicine. “Our findings support the idea that bacteriids or other bacteria and viruses that infect them play a role in the pathological process that leads to diabetes.”

    Viruses can cause type 1 and type 2 diabetes because they contain proteins that mimic insulin , an unexpected discovery.

    Researchers at Harvard University have found that four types of viruses produce proteins that mimic insulin, which can lead to diabetes in people exposed to microorganisms.

    Centenarians


    Long-livers should be examined for the presence of herpes, cytomegalovirus, Epstein-Barr virus, and chickenpox virus in their bodies!

    Symptoms


    Since many viral infections do not create visible symptoms, the infection may go unnoticed.

    For some people, the only sign of a viral disease is flu symptoms.

    Symptoms that may occur include:

    abnormal heartbeat
    chest pain
    fatigue
    fever
    muscle pain
    sore throat
    joint or foot pain or swelling
    swoon or shortness of breath

    Treatment


    Epstein virus - Barr (type 4 human herpes virus) is not treated, only the symptoms are relieved.

    Adults with chickenpox take 800 mg acyclovir tablets five times every day.

    Treating a viral infection may include medications, such as antiviral agents for treating an infection:

    • acyclovir
    • valaciclovir
    • famciclovir
    • penciclovir
    • docosanol

    A mild cytomegalovirus infection is usually not treated or valganciclovir, ganciclovir, cidofovir, foscarnet or a combination are taken.

    • Lysine - An increase in cellular lysine concentration upsets the HSV balance between lysine and arginine and inhibits virus replication.
    • Doctors may also recommend certain lifestyle changes, such as a low-salt diet and decreased activity.
    • Also, bacterial protection against viruses is being carried out all over the world. To date, it has been proven that the introduction of streptococcus symbiotic bacteria into the human body leads to a sharp decrease in the viral load on the body.

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